The goal of the NeuroMac initiative

The goal of the NeuroMac initiative is to obtain insights into the diverse functions of myeloid cells in the CNS during development, health and disease. A particular focus will be on parenchymal macrophages (microglia), circulating monocytes and bone marrow myeloid cells (e.g. myeloid progenitors). Combining studies of brain myeloid cell development and homeostasis, neurobiology, cell migration and neuropathology in one research initiative will enable a fruitful and productive interaction between the groups involved.

Research Program

Publications

Chotima Böttcher, Camila Fernández-Zapata, Stephan Schlickeiser, Desiree Kunkel, Axel R Schulz, Henrik E Mei, Carl Weidinger, René M Gieß, Susanna Asseyer, Britta Siegmund, Friedemann Paul, Klemens Ruprecht, Josef Priller: Multi-parameter immune profiling of peripheral blood mononuclear cells by multiplexed single-cell mass cytometry in patients with early multiple sclerosis. Sci Rep 9(1):19471. doi: 10.1038/s41598-019-55852-x 8 (2019).

Sankowski R, Strohl JJ, Huerta TS, Nasiri E, Mazzarello AN, D’Abramo C, Cheng KF, Staszewski O, Prinz M, Huerta PT, and Al-Abed Y. Endogenous retroviruses are associated with hippocampus-based memory impairment. PNAS 116 (51) 25982-25990; doi.org/10.1073/pnas.182216411 (2019).

R Mathew N, Vinnakota JM, Apostolova P, Erny D, Hamarsheh S, Andrieux G, Kim JS, Hanke K, Goldmann T, Chappell-Maor L, El-Khawanky N, Ihorst G, Schmidt D, Duyster J, Finke J, Blank T, Boerries M, Blazar BR, Jung S, Prinz M, Zeiser R. Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia. J Clin Invest, pii: 130272; doi: 10.1172/JCI130272 (2019).

Laufey Geirsdottir, Eyal David, Hadas Keren-Shaul, Assaf Weiner Stefan, Cornelius Bohlen,  JanaNeuber, Adam Balic, Amir Giladi, Fadi Sheban, Charles-Antoine Dutertre, Christine Pfeifle, Francesca Peri, Antonella Raffo-Romero, Jacopo Vizioli, Kaspar Matiasek, Christian Scheiwe, Stephan Meckel, Kerstin Mätz-Rensing, Franziska van der Meer, Finnbogi Rutur Thormodsson Christine Stadelmann, NogaZilkha, Tali Kimchi, Florent Ginhoux, Igor Ulitsky, Daniel Erny, Ido Amit, Marco Prinz: Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program. Cell 179 (7), 1609-1622.e16; doi: 10.1016/j.cell.2019.11.010 (2019).

Jörn F Ziegler JF, Chotima Böttcher, Marilena Letizia, Cansu Yerinde, Hao Wu, Inka Freise, Yasmina Rodriguez-Sillke , Ani K Stoyanova, Martin E Kreis, Patrick Asbach, Desiree Kunkel, Josef Priller, Ioannis Anagnostopoulos, Anja A Kühl, Konstanze Miehle, Michael Stumvoll, Florian Tran, Broder Fredrich, Michael Forster, Andre Franke, Christian Bojarski, Rainer Glauben, Britt-Sabina Löscher, Britta Siegmund, Carl Weidinger C: Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn’s disease. Nat Commun 10, 5629; doi.org/10.1038/s41467-019-13559-7 (2019).