Yagel G, Rimini D, von Locquenghien M, Avellino R, Barboy O, Chalan P, Granot G, Xie K, Shlomi-Loubaton S, Sheban F, Mazuz K, David E, Zwicky P, Amit I: Tumor-antigen-independent targeting of solid tumors by armored macrophage-directed anti-TREM2 CAR T cells. Cancer Cell S1535-6108(25)00502-1; doi: 10.1016/j.ccell.2025.11.009 (2026).
Hafner P, Keller SJ, Chen X, Alrawashdeh A, Jumaa H, Nollmann FI, Besson S, Kemming J, Gorka O, Das T, Appiah B, Lehmann A, Li M, Apostolova P, Bengsch B, Zeiser R, Tholen S, Schilling O, Groß O, Vlachos A, Wittel UA, von Elverfeldt D, Reichardt W, Boerries M, Andrieux G, Heynen GJ, Fichtner-Feigl S, Hannibal L, Ruess DA: Vertical RAS pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterations. Signal Transduct Target Ther 11:33; doi: 10.1038/s41392-025-02563-7 (2026).
Heitmann JS, Maringer Y, Jung S, Wacker M, Hackenbruch C, Polster M, Marconato M, Nelde A, Bauer J, Zwick M, Baur A-S, Lehmann A, Krolla C, Andrieux G, Köhler N, Boerries M, Denk M, Zieschang L, Kammer C, Hoenisch-Gravel N, Richter M, Oezbek MT, Wirths S, Dengler A, Dubbelaar ML, Pumptow M, Martus P, Brüggemann M, Rammensee H-G, Salih HR, Walz JS: Personalised multipeptide-based T-cell activator for chronic lymphocytic leukaemia: an open-label, single-centre, phase 1 study. Lancet Haematol S2352-3026(25)00323-0: doi: 10.1016/S2352-3026(25)00323-0 (2026).
Watter M, Giuliani C, Benadi G, Engel F, Binder H, Kaier K: Automated identification of contextually relevant biomedical entities with grounded LLMs. Sci Rep 16:1952; doi: 10.1038/s41598-026-35492-8 (2026).
Kaier K, Engel F, Benadi G, Guiliani C, Watter M, Kalantari A, Schuller K, Franzke C-W, Sperandio M; Binder H: Identification of biomedical entities from multiple repositories using a specialized metadata schema and search-augmented large language models. BMC Res Notes 19:43; doi: 10.1186/s13104-026-07632-w (2026).
Merck P-A, Lösslein AK, Neuber J, Schwer S, Jonas W, Pospisilik JA, Hilgendorf I, Henneke P, LOhrmann F: Low-density lipoprotein cholesterol drives multinucleated giant cell formation in response to mycobacterium bovis Bacille Calmette-Guérin. Sci Rep 16:802. doi: 10.1038/s41598-025-34088-y (2026).
Grün S, Rensing-Ehl A, Suske T, Wolter-Mess J, Gehrig J, Mann J, König C, Hauri M, Heeg M, Leahy TR, Genevieve D, Gaillard J-B, Broly M, Bourdin A, Castro C, Seidel L, Bengsch B, Aichele P, Weißert K, Fernandez-Orth J, Schipperges V, Andrieux G, Boerries M, Cabezas-Wallscheid N, Erlacher M, Elling R, Speckmann C, Heller L, Schulte B, Lorenz M, Schwarz K, Moriggl R, Ehl S: Somatic STAT5BN642H mutations shape variable immune landscapes resulting in heterogenous immune diseases. J Allergy Clin Immunol S0091-6749(25)02190-6; doi: 10.1016/j.jaci.2025.12.993 (2025).
Srinivasan S, Subramanian S, Zhou H, Hoppmann A, Metzger P, Boerries M, Ramamoorthy S: Synonymous and non-synonymous variants at splice junctions can disrupt splicing and are frequently linked to disease associated loss of function genes. BMC Genomics 27:99. doi: 10.1186/s12864-025-12466-0 (2025).
von Locquenghien M, Zwicky P, Xie K, Jaitin DA, Sheban F, Yalin A, Uhlitz F, Gur C, Eshed RS, David E, Mazuz K, Jennings Marin C, Sankar A, Mediratta D, Avellino R, Weiner A, Amit I: Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy. Cell 188(25):7099-7117.e26; doi: 10.1016/j.cell.2025.10.030 (2025).
Rassner M, Müller TA, Crossley KA, Andrieux GA, Schaberg S, Endres C, Jakob L, Poggio T, Köhler N, Kolter J, Müller-Newen G, Schönberger K, Cabezas-Wallscheid N, Gonzalez-Menendez I, Quintanilla-Martinez L, Zwick M, Ashok D, Hartmann TN, Groß O, Gorka O, Follo M, Illert AL, Boerries M, Zeiser R, Duyster J: Oncostatin M induced by STAT5-activating oncogenes promotes disease progression in hematologic malignancies. Signal Transduct Target Ther 10:400. doi: 10.1038/s41392-025-02491-6 (2025).
Stach LM, Huis In ‘t Veld 1 LGM, Schaub T, Jendrach M, Ornaghi M, Schwabenland M, Beling A, Pinkert S: Decoding IFN-mediated immunity and cell dynamics in viral encephalitis: Insights from coxsackievirus B3 infection. iScience 29(1):114324; doi: 10.1016/j.isci.2025.114324 (2025).
Friedmann D, Payne KJ, Cousin V, Andrieux G, Meng K, Schlaak AE, Unger S, Klocperk A, Geier C, Gräwe K, Pfeiffer J, Jakob TF, Hausmann O, Anhut P, Shabani M, Kurowski K, Rogg M, Aumann K, Seidl M, Provaznik J, Benes V, Boerries M, Boettler T, Schell C, Goldacker S, Keller B, Bengsch B, Warnatz K: Expansion of a distinct cytotoxic CD4 TFH-cell cluster in lymph nodes of patients with complicated common variable immunodeficiency.
J Allergy Clin Immunol S0091-6749(25)01144-3; doi: 10.1016/j.jaci.2025.09.032 (2025).
Weidling H, Motta E, Kuhrt LD, Krüger C, Andreeta Figueiredo C, Wallach T, Frahm S, Diecke S, Wolf SA, Kettenmann H, Lehnardt S: Extracellular microRNAs modulate human microglial function through TLR8. Front Immunol 16:1645062; doi: 10.3389/fimmu.2025.1645062 (2025).
Wenger V, Garcia-Manero G, Zeiser R, Lübbert M: DNA methyltransferase inhibitors in hematological malignancies and solid tumors. Int J Cancer 158(2):433–461; doi: 10.1002/ijc.70197 (2025).
Zähringer A, Vinnakota JM, Wertheimer T, Saalfrank P, Follo M, Ingelfinger F, Zeiser R: AIstain: Enhancing microglial phagocytosis analysis through deep learning. Cell Rep Methods 5(11):101207. doi: 10.1016/j.crmeth.2025.101207 (2025).
Gres V, Göcer M, Kolter J, Henneke P: Trained immunity in skin infections: Macrophages and beyond. eLife 14:e106688; doi: 10.7554/eLife.106688 (2025).
Petry P, Oschwald A, Merkt S, Dinh TLJ, Andrieux G, Crisand C, Botterer H, Nent E, Paterson N, Havermans M, Sankowski R, Schilling O, Boerries M, Amann L, Groß O, Schlitzer A, Prinz M, Lämmermann T, Kierdorf K: Early microglia progenitors colonize the embryonic CNS via integrin-mediated migration from the pial surface. Dev Cell S1534-5807(25)00532-5. doi: 10.1016/j.devcel.2025.08.012 (2025).
Kelm N, Kespohl M, Borowski S, Ochs S, Knobeloch K-P, Huis In ‘t Veld LGM, Klingel K, Beling A: Enhanced ISGylation via USP18 Isopeptidase Inactivation Fails to Mitigate the Inflammatory or Functional Course of Coxsackievirus B3-Induced Myocarditis. Cell Physiol Biochem 59(S3):1-21; doi: 10.33594/000000811 (2025).
Kolter J, Döring CL, Sarout S, Baasch S, Steele L, Alsumati R, Silva GVL, Silva CEA, Marques Paiva I, Mansoori Moghadam Z, Gres V, Lohrmann F, Aktories P, Buchegger T, Bijnen M, Doumard L, Voisin B, Le Foll C, Lachmann N, Greter M, Kierdorf K, Haniffa M, Cunha TM, Flacher V, Henneke H: Sensory neurons shape local macrophage identity via TGF-β signaling. Immunity S1074-7613(25)00367-X; doi: 10.1016/j.immuni.2025.08.004 (2025).
Braun LM, Lu Y, Zeiser R: Clinical perspective and treatment of immune-related colitis after cancer immunotherapy. Trends Cancer 11(11):1058-1077; doi: 10.1016/j.trecan.2025.07.005 (2025).
Frosch M, Shimizu T, Wogram E, Amann L, Gruber L, Groisman AI, Fliegauf M, Schwabenland M, Chhatbar C, Zechel S, Rosewich H, Gärtner J, Quintana FJ, Buescher JM, Blank T, Binder H, Stadelmann C, Letzkus JJ, Hopf C, Masuda T, Knobeloch K-P & Prinz M: Microglia–neuron crosstalk via Hex–GM2– MGL2 maintains brain homeostasis. Nature; doi: 10.1038/s41586-025-09477-y (2025).
Eckert P, Nöller M, Müller M, Haas R, Ruf J, Franz H, Moos K, Yu J-A, Zhao D, Xie W, Boerries M, Walz G, Yakulov TA: Targeting GLP-1 Signaling Ameliorates Cystogenesis in a Zebrafish Model of Nephronophthisis.
Int J Mol Sci 26(15):7366; doi: 10.3390/ijms26157366 (2025).
Zähringer A, Vinnakota JM, Wertheimer T, Follo M, Zeiser R: Protocol for performing and analyzing a live-cell imaging-based microglia phagocytosis assay using AI on the Olympus ScanR system. STAR Protoc 6(3):103846; doi: 10.1016/j.xpro.2025.103846 (2025).
Sheban F, San Phan T, Xie K, Ingelfinger F, Gur C, Shapir Itai Y, Blecher-Gonen R, Yu C, Avellino R, Chalan P, Freitag K, Yofe I, Yutkin V, Boyeau P, Ergen C, Hong J, Mazuz K, Liu Y, Chen K, Dahan R, Kortylewski M, Yosef N, Weiner A, Amit I: ZEB2 is a master switch controlling the tumor-associated macrophage program. Cancer Cell 43(7):1227-1241.e11; doi: 10.1016/j.ccell.2025.03.021 (2025).
Ardura-Fabregat A, Bosch LFP, Wogram E, Mossad O, Sankowski R, Aktories P, Kieger L, Cook J, Hasavci D, Ulupinar H, Brock D, Wang F, Iovino N, Wald S, Preissl S, Yilmaz B, Schnepf D, Macpherson AJ, Blank T, Kierdorf K, Prinz M: Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease. Nat Neurosci; doi: 10.1038/s41593-025-02006-0 (2025).
Chatterjee S, Rückert T, Martin I, Michaeli E, Buescher J, Apostolova P, Erny D, Lalioti ME, Biavasco F, Hartmann A, Runge S, Braun LM, Talvard-Balland N, Adams RC, Schmitt-Graeff A, Cook J, Wenger V, Athanassopoulos D, Hasavci D, Vallejo-Janeta AP, Blank T, Schaible P, Vinnakota JM, Zähringer A, Ganal-Vonarburg SC, Melchinger W, Pfeifer D, Köhler N, Rosshart SP, Michonneau D, Socié G, Andrieux G, Cabezas-Wallscheid N, Boerries M, Prinz M, Zeiser R. Gut microbiota-derived TMAVA is a modulator of acute CNS-GVHD. J Exp Med 222(9):e20242180; doi: 10.1084/jem.20242180 (2025).
Lu H, Diaz-Pier S, Lenz M, Vlachos A: The interplay between homeostatic synaptic scaling and homeostatic structural plasticity maintains the robust firing rate of neural networks. eLife 12:RP88376; doi: 10.7554/eLife.88376 (2025).
Seidl M, Bavafaye Haghighi E, Lösslein AK, Hufnagel M, Lohrmann F, Schneider C, Kohlfürst DS, Zenz W, Gorkiewicz G, Feiterna-Sperling C, Krüger R, Bronsert P, Neppl C, Sommer KZ, Stehl V, Boerries M, Kuntz M, Henneke P: Immunopathogenic and clinical implications of advanced tissue analysis in non-tuberculous mycobacterial infections in children. Front Immunol 16:1597074; doi: 10.3389/fimmu.2025.1597074 (2025).
Runge S, von Zedtwitz S, Maucher AM, Bruno P, Osbelt L, Zhao B, Gernand AM, Lesker TR, Gräwe K, Rogg M, Schell C, Boerries M, Strowig T, Andrieux G, Hild B, Stephan P Rosshart: Laboratory mice engrafted with natural gut microbiota possess awildling-like phenotype. Nat Commun 16(1):5301; doi: 10.1038/s41467-025-60554-2 (2025).
Kim J-S, Trzebanski S, Shin S-H, Schori L, Frumer Friedman GR, Noa Chapal Ilani NC, Kadam A, Vicario R, Aust O, Bugaeva P, Piatek S, Ismajli LK, Hoffmann CJ, Scheller M, Boura-Halfon S, Kaushansky N, Golani O, Solomon A, Liu Z, Amann L, Böhm-Sturm P, Koch SP, Wenger N, Netherlands Brain Bank, Ginhoux F, Prinz M, Avraham R, Harms C, Geissmann F, Müller-Tidow C, Uderhardt S, Milenkovic I, Shlush L, Jung S: Clonal hematopoiesis-associated motoric deficits caused by monocyte-derived microglia accumulating in aging mice. Cell Rep 44(5):115609; doi: 10.1016/j.celrep.2025.115609 (2025).
Sankowski R & Prinz M: A dynamic and multimodal framework to define microglial states. Nat Neurosci; doi: 10.1038/s41593-025-01978-3 (2025).
Teng Y-H, Appiah B, Andrieux G, Schrempp M, Rose K, Hofmann AS, Ku M, Beyes S, Boerries M, Hecht A: TGF-β signaling redirects Sox11 gene regulatory activity to promote partial EMT and collective invasion of oncogenically transformed intestinal organoids. Oncogenesis 14(1):17; doi: 10.1038/s41389-025-00560-7 (2025).
Frosch M & Prinz M: Niche-specific therapeutic targeting of myeloid cells in the central nervous system. Immunity 58(5):1101-1119; doi: 10.1016/j.immuni.2025.03.016 (2025).
Zimmermann J, Boudriot C, Eipert C, Hoffmann G, Nuttall R, Neumaier V, Bonhoeffer M, Schneider S, Schmitzer L, Kufer J, Kaczmarz S, Hedderich DM, Ranft A, Golkowski D, Priller J, Zimmer C, Ilg R, Schneider G, Preibisch C, Sorg C, Zott B: Total cerebral blood volume changes drive macroscopic cerebrospinal fluid flux in humans. PLoS Biol 23(4):e3003138; doi: 10.1371/journal.pbio.3003138 (2025).
Kumbol V, Ivanov A, McGurran H, Schüler J, Zhai Y, Ludwik K, Hinkelmann L, Brehm M, Krüger C, Küchler J, Wallach T, Höltje M, Beule D, Stachelscheid H, Lehnardt S: Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability. Cell Commun Signal 23(1):196; doi: 10.1186/s12964-025-02199-8 (2024).
Wang M, Otto C, Fernández Zapata C, Dehlinger A, Gallaccio G, Diekmann L-M, Niederschweiberer M, Schindler P, Körtvélyessy P, Kunkel D, Paul F, Ruprecht K, Böttcher C: Comprehensive analysis of B cell repopulation in ocrelizumab-treated patients with multiple sclerosis by mass cytometry and proteomics. iScience 28(5):112383; doi: 10.1016/j.isci.2025.112383 (2025).
Lösslein AK, Henneke P: Macrophage Differentiation and Metabolic Adaptation in Mycobacterial Infections. Annu Rev Immunol 43(1):423-450; doi: 10.1146/annurev-immunol-082323-120757 (2025).
Schlösser RM, Krumbach F, Corrales E, Andrieux G, Preisinger C, Liss F, Golzmann A, Boerries M, Becker K, Knüchel R, Garczyk S, Lüscher B: Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal-like and malignant urothelial cells. Mol Oncol; doi: 10.1002/1878-0261.70019 (2025).
Zimmermann J, Sorg C, Müller L, Zistler F, Neumaier V, Bonhoeffer M, Ranft A, Golkowski D, Priller J, Zimmer C, Ilg R, Preibisch C, Schneider G, Nuttall R, Zott B: Impaired Macroscopic Cerebrospinal Fluid Flow by Sevoflurane in Humans during and after Anesthesia. Anesthesiology 142(4):692-703; doi: 10.1097/ALN.0000000000005360 (2025).
Zähringer A, Morgado I, Erny D, Ingelfinger F, Gawron J, Chatterjee S, Wenger V, Schmidt D, Schwöbel LF, Adams RC, Langenbach M, Hartmann A, Osswald N, Wolf J, Schlunck G, Briquez PS, Grueter K, Ruess DA, Frew I, Burk A-C, Holzmüller V, Grimbacher B, Michonneau D, Andrieux G, Socié G, Kolter J, Börries M, Follo M, Blaeschke F Sevenich L, Prinz M, Zeiser R, Vinnakota JM: AhR activation mitigates graft-versus-host disease of the central nervous system by reducing microglial NF-κB signaling. Blood Adv; doi: 10.1182/bloodadvances.2024015000 (2025).
d’Errico P, Früholz I, Meyer-Luehmann M, Vlachos A: Neuroprotective and plasticity promoting effects of repetitive transcranial magnetic stimulation (rTMS): A role for microglia. Brain Stimul 18(3):810-821; doi: 10.1016/j.brs.2025.03.012 (2025).
Schaible P, Henschel J, Erny D: How the gut microbiota impacts neurodegenerative diseases by modulating CNS immune cells.
J Neuroinflammation 22(1):60; doi: 10.1186/s12974-025-03371-0 (2025).
Kelm N, Kespohl M, Smagurauskaite G, Vales S, Karuppanan K, Mburu P, Thiele A, Pinkert S, Bukur T, Mülleder M, Berndt N, Klingel K, Gaida MM, Bhattacharya S, Beling A: Assessing customized multivalent chemokine‑binding peptide treatment in a murine model of coxsackievirus B3 myocarditis. Basic Res Cardiol 120(2):393-422; doi: 10.1007/s00395-025-01098-w (2025).
