Projects : SFB/TRR 167

Project Area A: Factors regulating the fate and function of brain macrophages

Prof. Dr. Marco Prinz
Dr. Lukas Amann

Deciphering cellular interactions in CNS macrophage niches in mice and humans by spatial proteogenomics

Prof. Steffen Jung
Dr. Liran Shlush

Monocyte-derived microglia and the impact of clonal hematopoiesis on the brain

Prof. Dr. Ido Amit
Dr. Hadas Keren-Shaul

Massively parallel single-cell CRISPR screen for development of novel microglia targeting immunotherapies in Alzheimer’s Disease

Prof. Dr. Daniel Erny
PD Dr. Thomas Blank

How gut metabolites dictate CNS macrophages functi on in steady state, aging and neurodegenerati on

Dr. Katrin Kierdorf
Prof. Dr. Olaf Groß

Mechanisms and consequences of microglia elimination during postnatal development

Prof. Dr. Simon Schäfer
Prof. Dr. Josef Priller

Decoding human microglia phenotypes in the context of neuropsychiatric disorders

Prof. Dr. Martin Kerschensteiner
Prof. Dr. Thomas Misgeld

Metabolic regulation of macrophage function in the inflamed central nervous system

Project Area B: Myeloid cells in brain diseases

Prof. Dr. Seija Lehnardt
Dr. Michelle Vincedeau

The role of human endogenous retrovirus K as a modulator of microglial function in glioblastoma

Prof. Dr. Philipp Henneke
Dr. Anne Kathrin Lößlein

Role of CNS-associated macrophages in mycobacterial meningoencephalitis

PD Dr. Chotima Böttcher
PD Dr. Carolin Otto

Association of myeloid cell and gut-derived B-cell diversity with disease activity and severity in mulitple sclerosis

Prof. Dr. Robert Zeiser
Jun.-Prof. Dr. Natalie Köhler

Deciphering the role of intestinal microbiome-derived metabolites on microglial activation during GVHD and ICANS

Prof. Dr. Josef Priller
Prof. Dr. Marco Prinz

Development and context-dependent plasti city of brain macrophages

Prof. Dr. Andreas Meisel
Dr. Shima Safaiyan

Role of microglia in chronic neuroinflammation and long-term consequences aft er stroke

Prof. Dr. Andreas Vlachos
Prof. Dr. Melanie Meyer-Lühmann

Impact of amyloid-β on microglia-mediated synaptic plasticity in the rodent and human cortex

PD Dr. Klaus-Peter Knobeloch
Prof. Dr. Antje Beling

USP18 as an immune checkpoint regulator for microglia activation

Integrated Research Training Group

Prof. Dr. Josef Priller

NeuroMac School

Core Projects

Prof. Dr. Dr. Melanie Börries
Prof. Dr. Harald Binder
Prof. Dr. Julijana Gjorgjieva

Bioinformatics-Modeling Core

Get in contact

Coordinator
Tanja Wilde, M.A.
Medical Center – University of Freiburg

+49 (0)761 / 270-51190 tanja.wilde@uniklinik-freiburg.de

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