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Development, function and potential of myeloid cells in the central nervous system.
Development, function and potential of myeloid cells in the central nervous system.
Development, function and potential of myeloid cells in the central nervous system.
Development, function and potential of myeloid cells in the central nervous system.

Projects

People

Graduate Program (IRTG)

The goal of NeuroMac

The main goals of the third funding period are to better understand the molecular mechanisms of myeloid cell
diversity in the CNS and the interactions of microglia and CAMs with neurons, macroglia and vascular cells during brain development, homeostasis and disease. In detail, we want to. In detail, we want to:

  • explore the molecular mechanisms and environmental factors that determine myeloid cell identity in the healthy and diseased CNS (Project area A) (Area A)
  • examine the spatial distribution and local cellular interactions of brain myeloid cells (Project area A) (Area A)
  • identify the cellular mechanisms, metabolic signals and sex-dependent cues for the establishment of contextassociated microglia states and the interactions of myeloid cells with other cells in the affected CNS (Project areas A, B) (Areas A, B)
  • develop strategies for therapeutic targeting of myeloid cells in CNS disorders (Project area B) (Area B)
Research Program

Seminars

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News

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Publications

Wang M, Otto C, Fernández Zapata C, Dehlinger A, Gallaccio G, Diekmann LM, Niederschweiberer M, Schindler P, Körtvélyessy P, Kunkel D, Paul F, Ruprecht K, Böttcher C. Comprehensive analysis of B cell repopulation in ocrelizumab-treated patients with multiple sclerosis by mass cytometry and proteomics. iScience. iScience 28(5):112383; doi: 10.1016/j.isci.2025.112383 (2025).

Schaible P, Henschel J, Erny D: How the gut microbiota impacts neurodegenerative diseases by modulating CNS immune cells.
J Neuroinflammation 22(1):60; doi: 10.1186/s12974-025-03371-0 (2025).

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Get in contact

Coordinator
Tanja Wilde, M.A.
Medical Center – University of Freiburg

+49 (0)761 / 270-51190 tanja.wilde@uniklinik-freiburg.de

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Technische Universität München
Logo Albert-Ludwigs-Universität Freiburg
Logo Universitätsklinikum Freiburg
Logo Charité – Universitätsmedizin Berlin
Ludwig-Maximilians-Universität München
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