Publications

Yagel G, Rimini D, von Locquenghien M, Avellino R, Barboy O, Chalan P, Granot G, Xie K, Shlomi-Loubaton S, Sheban F, Mazuz K, David E, Zwicky P, Amit I: Tumor-antigen-independent targeting of solid tumors by armored macrophage-directed anti-TREM2 CAR T cells. Cancer Cell S1535-6108(25)00502-1; doi: 10.1016/j.ccell.2025.11.009 (2026).

Hafner P, Keller SJ, Chen X, Alrawashdeh A, Jumaa H, Nollmann FI, Besson S, Kemming J, Gorka O, Das T, Appiah B, Lehmann A, Li M, Apostolova P, Bengsch B, Zeiser R, Tholen S, Schilling O, Groß O, Vlachos A, Wittel UA, von Elverfeldt D, Reichardt W, Boerries M, Andrieux G, Heynen GJ, Fichtner-Feigl S, Hannibal L, Ruess DA: Vertical RAS pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterations. Signal Transduct Target Ther 11:33; doi: 10.1038/s41392-025-02563-7 (2026).

Heitmann JS, Maringer Y, Jung S, Wacker M, Hackenbruch C, Polster M, Marconato M, Nelde A, Bauer J, Zwick M, Baur A-S, Lehmann A, Krolla C, Andrieux G, Köhler N, Boerries M, Denk M, Zieschang L, Kammer C, Hoenisch-Gravel N, Richter M, Oezbek MT, Wirths S, Dengler A, Dubbelaar ML, Pumptow M, Martus P, Brüggemann M, Rammensee H-G, Salih HR, Walz JS: Personalised multipeptide-based T-cell activator for chronic lymphocytic leukaemia: an open-label, single-centre, phase 1 study. Lancet Haematol S2352-3026(25)00323-0: doi: 10.1016/S2352-3026(25)00323-0 (2026).

Watter M, Giuliani C, Benadi G, Engel F, Binder H, Kaier K: Automated identification of contextually relevant biomedical entities with grounded LLMs. Sci Rep 16:1952; doi: 10.1038/s41598-026-35492-8 (2026).

Kaier K, Engel F, Benadi G, Guiliani C, Watter M, Kalantari A, Schuller K, Franzke C-W, Sperandio M; Binder H: Identification of biomedical entities from multiple repositories using a specialized metadata schema and search-augmented large language models. BMC Res Notes 19:43; doi: 10.1186/s13104-026-07632-w (2026).

McGurran H, Graceffo E, Kumbol V, Jendrach M, Hinkelmann L, Brehm M, Ravatt L, Krüger C, Wallach T, Haake A, Wegmann S, Heppner FL, Schülke M, Lehnardt S: MicroRNA-29a-5p contributes to neuroinflammation through TLR7.  J Neuroinflammation 23(1):38; doi: 10.1186/s12974-025-03680-4 (2026).

Merck P-A, Lösslein AK, Neuber J, Schwer S, Jonas W, Pospisilik JA, Hilgendorf I, Henneke P, LOhrmann F: Low-density lipoprotein cholesterol drives multinucleated giant cell formation in response to mycobacterium bovis Bacille Calmette-Guérin. Sci Rep 16:802. doi: 10.1038/s41598-025-34088-y (2026).

Grün S, Rensing-Ehl A, Suske T, Wolter-Mess J, Gehrig J, Mann J, König C, Hauri M, Heeg M, Leahy TR, Genevieve D, Gaillard J-B, Broly M, Bourdin A, Castro C, Seidel L, Bengsch B, Aichele P, Weißert K, Fernandez-Orth J, Schipperges V, Andrieux G, Boerries M, Cabezas-Wallscheid N, Erlacher M, Elling R, Speckmann C, Heller L, Schulte B, Lorenz M, Schwarz K, Moriggl R, Ehl S: Somatic STAT5B^N642H mutations shape variable immune landscapes resulting in heterogenous immune diseases. J Allergy Clin Immunol S0091-6749(25)02190-6; doi: 10.1016/j.jaci.2025.12.993 (2025).

Srinivasan S, Subramanian S, Zhou H, Hoppmann A, Metzger P, Boerries M, Ramamoorthy S: Synonymous and non-synonymous variants at splice junctions can disrupt splicing and are frequently linked to disease associated loss of function genes. BMC Genomics 27:99. doi: 10.1186/s12864-025-12466-0 (2025).

von Locquenghien M, Zwicky P, Xie K, Jaitin DA, Sheban F, Yalin A, Uhlitz F, Gur C, Eshed RS, David E, Mazuz K, Jennings Marin C, Sankar A, Mediratta D, Avellino R, Weiner A, Amit I: Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy. Cell 188(25):7099-7117.e26; doi: 10.1016/j.cell.2025.10.030 (2025).

Rassner M, Müller TA, Crossley KA, Andrieux GA, Schaberg S, Endres C, Jakob L, Poggio T, Köhler N, Kolter J, Müller-Newen G, Schönberger K, Cabezas-Wallscheid N, Gonzalez-Menendez I, Quintanilla-Martinez L, Zwick M, Ashok D, Hartmann TN, Groß O, Gorka O, Follo M, Illert AL, Boerries M, Zeiser R, Duyster J: Oncostatin M induced by STAT5-activating oncogenes promotes disease progression in hematologic malignancies. Signal Transduct Target Ther 10:400. doi: 10.1038/s41392-025-02491-6 (2025).

de la Rosa C, Kendirli A, Baygün S, Bauernschmitt F, Thomann AS, Kisioglu I, Beckmann D, Carpentier Solorio Y, Pfaffenstaller V, Tai Y-H, Mehraein N, Sanchez P, Spieth L, Gerdes LA, Beltran E, Dornmair K, Simons M, Peters A, Schmidt-Supprian M, Kerschensteiner M: In vivo CRISPR screen reveals regulation of macrophage states in neuroinflammation. Nat Neurosci; doi: 10.1038/s41593-025-02151-6 (2025).

Stach LM, Huis In ‘t Veld 1 LGM, Schaub T, Jendrach M, Ornaghi M, Schwabenland M, Beling A, Pinkert S: Decoding IFN-mediated immunity and cell dynamics in viral encephalitis: Insights from coxsackievirus B3 infection. iScience 29(1):114324; doi: 10.1016/j.isci.2025.114324 (2025).

Friedmann D, Payne KJ, Cousin V, Andrieux G, Meng K, Schlaak AE, Unger S, Klocperk A, Geier C, Gräwe K, Pfeiffer J, Jakob TF, Hausmann O, Anhut P, Shabani M, Kurowski K, Rogg M, Aumann K, Seidl M, Provaznik J, Benes V, Boerries M, Boettler T, Schell C, Goldacker S, Keller B, Bengsch B, Warnatz K: Expansion of a distinct cytotoxic CD4 T_FH-cell cluster in lymph nodes of patients with complicated common variable immunodeficiency.
J Allergy Clin Immunol S0091-6749(25)01144-3; doi: 10.1016/j.jaci.2025.09.032 (2025).

Weidling H, Motta E, Kuhrt LD, Krüger C, Andreeta Figueiredo C, Wallach T, Frahm S, Diecke S, Wolf SA, Kettenmann H, Lehnardt S: Extracellular microRNAs modulate human microglial function through TLR8. Front Immunol 16:1645062; doi: 10.3389/fimmu.2025.1645062 (2025).

Rodomonti M, Pache F, Otto C, Schindler P, Eberspächer B, Geran R, Puthenparampil M, Gallo P, Wildemann B, Jarius S, Erdur H, Ruprecht K: Retrospective In Silico Analysis of Routine Laboratory Data Supports a Specific Association of Epstein–Barr Virus and Multiple Sclerosis. Eur J Neurol 32(11):e70430; doi: 10.1111/ene.70430 (2025).