Publications

Wang M, Buthut M, Meinhardt J, Otto C, Gallaccio G, Fernández-Zapata C, Teves M, Samol C, Dettmer K, Heckscher S, Kamboj S, Bahar Y, Conrad C, Böttcher C, Kunkel D, Ruprecht K, Paul F, Oefner PJ, Radbruch H, Gronwald W, Prüß H, Böttcher C: Immune-proteo-metabolomic changes link to Aβ and tau pathology in Alzheimer disease. Alzheimers Dement 22(4):e71359; doi: 10.1002/alz.71359 (2026).

Chhatbar C, Sankowski R, Schulz M, Shimizu T, Schwabenland M, Staszewski O, Scheiwe C, Nessler S, Borst K, Dumas AA, Trost E, Berchtold D, Brandão W, Mossad O, Gasull AD, Frosch M, Erny D, Diebold M, Guffart E, Ternka K, Guranda M, Vinnakota JM, Friesen M, Ouk K, Waltl I, LaMorte M, Hammond TR, Di Liberto G, Vincenti I, Kreutzfeldt M, Mughrabi IT, Al-Abed Y, Blank T, Meyer-Luehmann M, Crow YJ, Hagen N, Ofengeim D, Zeiser R, Kettwig M, Gärtner J, Meisel A, Schwemmle M, Kalinke U, Beck J, Bengsch B, Thimme R, Butovsky O, Seredenina T, Ransohoff RM, Quintana FJ, Kierdorf K, Merkler D, Stadelmann C, Priller J & Prinz M: A transcriptomic microglia taxonomy across mouse and human pathologies. Nature Immunology; doi: 10.1038/s41590-026-02472-z (2026).

Fliegauf M, Amann L, Prinz M: CNS border macrophages in health and disease . J Immunol 215(S3):vkaf308; doi: 10.1093/jimmun/vkaf308 (2026).

Fliegauf M, Levard D, Cardamone F, Frosch M, Kuhn S, Sankowski R, Provinciali M, Dumas AA, Dalmau Gasull A, Aktories P, Oschwald A, Schwabenland M, Scholz R, Beyer MD, Neher JJ, Kollefrath M, Baltas D, Reichardt W, von Elverfeldt D, Vivien D, Cupovic J, Iovino N, Rubio M, Amann L & Prinz M: Distinct origins and niches determine the cellular responsiveness of CNS macrophages after repopulation. Nat Immunol doi: 10.1038/s41590-026-02457-y (2026).

Safaiyan S, Frosch M, Bickel T, Monaco G, Dvir R, Madry C, Bosch LFP, Kierdorf K, Innocenti, Priller J, Prinz M, Lämmermann T: The Arp2/3 complex controls the development of homeostatic microglia . EMBO Rep; doi: 10.1038/s44319-026-00721-8 (2026).

Maas SLN, Tang Y, Stutheit-Zhao E, Rahmanzade R, Blume C, Hielscher T, Zettl F, Benfatto S, Calafato D, Sill M, Benotmane JK, Yabo YA, Behling F, Suwala A, Kardo H, Ritter M, Peyre M, Sankowski R, Okonechnikov K, Sievers P, Patel A, Reuss D, Friedrich MJ, Stichel D, Schrimpf D, Van den Bosch TPP, Beck K, Wirsching H-G, Jungwirth G, Hanemann CO, Lamszus K, Etminan N, Unterberg A, Mawrin C, Remke M, Ayrault O, Lichter P, Reifenberger G, Platten M, Kacprowski T, List M, Pauling JK, Baumbach J, Milde T, Grossmann R, Ram Z, Ratliff M, Mallm J-P, Neidert MC, Bos EM, Prinz M, Weller M, Acker T, Hartmann FJ, Preusser M, Tabatabai G, Herold-Mende C, Krieg SM, Jones DTW, Pfister SM, Wick W, Kalamarides M, von Deimling A, Heiland DH, Hovestadt V, Gerstung M, Schlesner M, The German “Aggressive Meningiomas” Consortium (KAM) & Sahm F: A microenvironment-determined risk continuum refines subtyping in meningioma and reveals determinants of machine learning-based tumor classification. Nat Genet 58(2):341-354; doi: 10.1038/s41588-025-02475-w (2026).

Yagel G, Rimini D, von Locquenghien M, Avellino R, Barboy O, Chalan P, Granot G, Xie K, Shlomi-Loubaton S, Sheban F, Mazuz K, David E, Zwicky P, Amit I: Tumor-antigen-independent targeting of solid tumors by armored macrophage-directed anti-TREM2 CAR T cells. Cancer Cell S1535-6108(25)00502-1; doi: 10.1016/j.ccell.2025.11.009 (2026).

Hafner P, Keller SJ, Chen X, Alrawashdeh A, Jumaa H, Nollmann FI, Besson S, Kemming J, Gorka O, Das T, Appiah B, Lehmann A, Li M, Apostolova P, Bengsch B, Zeiser R, Tholen S, Schilling O, Groß O, Vlachos A, Wittel UA, von Elverfeldt D, Reichardt W, Boerries M, Andrieux G, Heynen GJ, Fichtner-Feigl S, Hannibal L, Ruess DA: Vertical RAS pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterations. Signal Transduct Target Ther 11:33; doi: 10.1038/s41392-025-02563-7 (2026).

Heitmann JS, Maringer Y, Jung S, Wacker M, Hackenbruch C, Polster M, Marconato M, Nelde A, Bauer J, Zwick M, Baur A-S, Lehmann A, Krolla C, Andrieux G, Köhler N, Boerries M, Denk M, Zieschang L, Kammer C, Hoenisch-Gravel N, Richter M, Oezbek MT, Wirths S, Dengler A, Dubbelaar ML, Pumptow M, Martus P, Brüggemann M, Rammensee H-G, Salih HR, Walz JS: Personalised multipeptide-based T-cell activator for chronic lymphocytic leukaemia: an open-label, single-centre, phase 1 study. Lancet Haematol S2352-3026(25)00323-0: doi: 10.1016/S2352-3026(25)00323-0 (2026).

Watter M, Giuliani C, Benadi G, Engel F, Binder H, Kaier K: Automated identification of contextually relevant biomedical entities with grounded LLMs. Sci Rep 16:1952; doi: 10.1038/s41598-026-35492-8 (2026).

Kaier K, Engel F, Benadi G, Guiliani C, Watter M, Kalantari A, Schuller K, Franzke C-W, Sperandio M, Binder H: Identification of biomedical entities from multiple repositories using a specialized metadata schema and search-augmented large language models. BMC Res Notes 19:43; doi: 10.1186/s13104-026-07632-w (2026).

McGurran H, Graceffo E, Kumbol V, Jendrach M, Hinkelmann L, Brehm M, Ravatt L, Krüger C, Wallach T, Haake A, Wegmann S, Heppner FL, Schülke M, Lehnardt S: MicroRNA-29a-5p contributes to neuroinflammation through TLR7.  J Neuroinflammation 23(1):38; doi: 10.1186/s12974-025-03680-4 (2026).

Merck P-A, Lösslein AK, Neuber J, Schwer S, Jonas W, Pospisilik JA, Hilgendorf I, Henneke P, Lohrmann F: Low-density lipoprotein cholesterol drives multinucleated giant cell formation in response to mycobacterium bovis Bacille Calmette-Guérin. Sci Rep 16:802. doi: 10.1038/s41598-025-34088-y (2026).

Grün S, Rensing-Ehl A, Suske T, Wolter-Mess J, Gehrig J, Mann J, König C, Hauri M, Heeg M, Leahy TR, Genevieve D, Gaillard J-B, Broly M, Bourdin A, Castro C, Seidel L, Bengsch B, Aichele P, Weißert K, Fernandez-Orth J, Schipperges V, Andrieux G, Boerries M, Cabezas-Wallscheid N, Erlacher M, Elling R, Speckmann C, Heller L, Schulte B, Lorenz M, Schwarz K, Moriggl R, Ehl S: Somatic STAT5B^N642H mutations shape variable immune landscapes resulting in heterogenous immune diseases. J Allergy Clin Immunol S0091-6749(25)02190-6; doi: 10.1016/j.jaci.2025.12.993 (2025).

Srinivasan S, Subramanian S, Zhou H, Hoppmann A, Metzger P, Boerries M, Ramamoorthy S: Synonymous and non-synonymous variants at splice junctions can disrupt splicing and are frequently linked to disease associated loss of function genes. BMC Genomics 27:99. doi: 10.1186/s12864-025-12466-0 (2025).

von Locquenghien M, Zwicky P, Xie K, Jaitin DA, Sheban F, Yalin A, Uhlitz F, Gur C, Eshed RS, David E, Mazuz K, Jennings Marin C, Sankar A, Mediratta D, Avellino R, Weiner A, Amit I: Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy. Cell 188(25):7099-7117.e26; doi: 10.1016/j.cell.2025.10.030 (2025).