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The goal of the NeuroMac initiative

The goal of the NeuroMac initiative is to obtain insights into the diverse functions of myeloid cells in the CNS during development, health and disease. A particular focus will be on parenchymal macrophages (microglia), circulating monocytes and bone marrow myeloid cells (e.g. myeloid progenitors). Combining studies of brain myeloid cell development and homeostasis, neurobiology, cell migration and neuropathology in one research initiative will enable a fruitful and productive interaction between the groups involved.

Research Program

Publications

Julia Kolter and Philipp Henneke: Codevelopment of Microbiota and Innate Immunity and the Risk for Group B Streptococcal Disease, Front Immunol. 8: 1497 (2017).

Katrin Kierdorf and Marco Prinz: Microglia in steady state, J Clin Invest. 127 (9), 3201-3209 (2017).

Nora Hagemeyer, Klara‑Maria Hanft, Maria‑Anna Akriditou, Nicole Unger, Eun S. Park, E. Richard Stanley, Ori Staszewski, Leda Dimou, Marco Prinz: Microglia contribute to normal myelinogenesis and to oligodendrocyte progenitor maintenance during adulthood, Acta Neuropathol (2017) 134: 441.

Diana Varol, Alexander Mildner, Thomas Blank, Anat Shemer, Neta Barashi, Simon Yona, Eyal David, Sigalit Boura-Halfon, Yifat Segal-Hayoun, Louise Chappell-Maor, Hadas Keren-Shaul, Dena Leshkowitz, Eran Hornstein, Martin Fuhrmann, Ido Amit, Nicola Maggio, Marco Prinz, and Steffen Jung: Dicer Deficiency Differentially ImpactsMicroglia of the Developing and Adult Brain, Immunity 46, 1030–1044 (2017).

Hadas Keren-Shaul, Amit Spinrad, Assaf Weiner, Orit Matcovitch-Natan, Raz Dvir-Szternfeld, Tyler K. Ulland, Eyal David, Kuti Baruch, David Lara-Astaiso, Beata Toth, Shalev Itzkovitz, Marco Colonna, Michal Schwartz, Ido Amit: A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease. Cell, Volume 169, Issue 7, p1276–1290.e17, 15 June 2017.