Publications

Salomon R, Rotem H, Katzenelenbogen Y, Weiner A, Saban NC, Feferman T, Amit I, Dahan R: Bispecific antibodies increase the therapeutic window of CD40 agonists through selective dendritic cell targeting. Nat Cancer 3(3), 287-302, doi: 10.1038/s43018-022-00329-6 (2022).

Ravi VM, Neidert N, Will P, Joseph K, Maier JP, Kückelhaus J, Vollmer L, Goeldner JM, Behringer SP, Scherer F, Boerries M, Follo M, Weiss T, Delev D, Kernbach J, Franco P, Schallner N, Dierks C, Carro MS, Hofmann UG, Fung C, Sankowski R, Prinz M, Beck J, Salié H, Bengsch B, Schnell O and Heiland DH: T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10. Nat Commun 13: 925; doi: 10.1038/s41467-022-28523-1 (2022).

Kasapi A, Triantafyllopoulou A: Genotoxic stress signalling as a driver of macrophage diversity. Cell Stress 6(3), 30-44, doi: 10.15698/cst2022.03.265 (2022).

Sankowski R, Monaco G, Prinz M: Evaluating microglial phenotypes using single-cell technologies. Trends Neurosci 45(2):133-144; doi: 10.1016/j.tins.2021.11.001 (2022).

Voss M, Kleinau G, Gimber N, Janek K, Bredow C, Thery F, Impens F, SchmoranzeJ, Scheerer P, Kloetzel P-M, Beling A: A cytosolic disulfide bridge-supported dimerization is crucial for stability and cellular distribution of Coxsackievirus B3 protein 3A. FEBS J 289(13), 3826-3838, doi: 10.1111/febs.16368 (2022).

Lopes KdP, Snijders GJL, Humphrey J, Allan A, Sneeboer MAM, Navarro E, Schilder BM, Vialle RA, Parks M, Missall R, van Zuiden W, Gigase FAJ, Kübler R, van Berlekom AB, Hicks EM, Bӧttcher C, Priller J, Kahn RS, de Witte LD, Raj T: Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies. Nat Genet 54(1), 4-17 (2022).

Suwala AK, Felix M, Friedel D, Stichel D, Schrimpf D, Hinz F, Hewer E, Schweizer L, Dohmen H, Pohl U, Staszewski O, Korshunov A, Stein M, Wongsurawat T, Cheunsuacchon P, Sathornsumetee S, Koelsche C, Turner C, Le Rhun E, Mühlebner A, Schucht P, Özduman K, Ono T, Shimizu H, Prinz M, Acker T, Herold-Mende C, Kessler T, Wick W, Capper D, Wesseling P, Sahm F, von Deimling A, Hartmann C, Reuss DE: Oligosarcomas, IDH-mutant are distinct and aggressive. Acta Neuropathol 143(2):263-281; doi: 10.1007/s00401-021-02395-z (2022).

Mossad O, Nent E, Woltemate S, Folschweiller S, Buescher JM, Schnepf D, Erny D, Staeheli P, Bartos M, Szalay A, Stecher B, Vital M, Sauer JF, Lämmermann T, Prinz M, Blank T: Microbiota-dependent increase in δ-valerobetaine affects neuronal synchronicity and mediates age-related cognitive decline. Nature Aging 1, 1127-1136 (2021).

Wallach T*, Mossmann ZJ*, Szczepek M, Wetzel M, Machado R, Raden M, Miladi M, Kleinau G, Krüger C, Dembny P, Adler D, Zhai Y, Kumbol V, Dzaye O, Schüler J, Futschik M, Backofen R, Scheerer P, Lehnardt S: MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration.
Mol Neurodegener 16(1):80 (2021). *equal contribution

d’Errico P, Ziegler-Waldkirch S, Aires V, Hoffmann P, Mezö C, Erny D, Sebastian Monasor L, Liebscher S, Ravi VM, Joseph K, Schnell O, Kierdorf K, Staszewski O, Tahirovic S, Prinz M, Meyer-Luehmann M: Microglia contribute to the propagation of Aβ into unaffected brain tissue. Nat Neurosci 25(1):20-25; doi: 10.1038/s41593-021-00951-0 (2021).

El Khawanky N, Hughes A, Yu W, Myburgh R, Matschulla T, Taromi S, Aumann K, Clarson J, Vinnakota JM, Shoumariyeh K, Miething C, Lopez AF, Brown MP, Duyster J, Hein L, Manz MG, Hughes TP, White DL, Yong ASM, Zeiser R: Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia. Nat Commun 12(1), 6436, doi: 10.1038/s41467-021-26683-0 (2021).

Erny D, Dokalis N, Mezö C, Castoldi A, Mossad O, Staszewski O, Frosch M, Villa M, Fuchs V, Mayer A, Neuber J, Sosat J, Tholen S, Schilling O, Vlachos A, Blank T, Gomez de Agüero M, Macpherson AJ, Pearce EJ, Prinz M: Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease. Cell Metab 33(11); 2260-2276.e7 (2021).

Sankowski R, Ahmari J, Mezö C, Hrabě de Angelis AL, Fuchs V, Utermöhlen O, Buch T, Blank T, Gomez de Agüero M, Macpherson AJ, Erny D: Commensal microbiota divergently affect myeloid subsets in the mammalian central nervous system during homeostasis and disease. EMBO J, e108605; doi: 10.15252/embj.2021108605 (2021).

Zhang P, Schlecht A, Wolf J, Boneva S, Laich Y, Koch J, Ludwig F, Boeck M, Thien A, Härdtner C, Kierdorf K, Agostini H, Schlunck G, Prinz M, Hilgendorf I, Wieghofer P & Lange C: The role of interferon regulatory factor 8 for retinal tissue homeostasis and development of choroidal neovascularisation. Journal of Neuroinflammation 18, 215 (2021).

Klammer MG, Dzaye O, Wallach T, Krüger C, Gaessler D, Buonfiglioli A, Derkow K, Kettenmann H, Brinkmann MM, Lehnardt S: UNC93B1 is widely expressed in the murine CNS and is required for neuroinflammation and neuronal injury induced by microRNA let-7b. Front Immunol 12:715774 (2021).

Ifuku M, Hinkelmann L, Kuhrt LD, Efe IE, Kumbol V, Buonfiglioli A, Krüger C, Jordan P, Fulde M, Noda M, Kettenmann H*, Lehnardt S*: Activation of Toll-like receptor 5 in microglia modulates their function and triggers neuronal injury. Acta Neuropathol Commun 8(1):159 (2020). *Equal contribition.