Targeting TGF-β-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity-syndrome (ICANS)

Vinnakota, JM, Biavasco, F, Schwabenland, M, Chatbar, C, Adams, RC, Erny, D, Duquesne, S, El Khawanky, N, Schmidt, D, Fetsch, V, Zähringer, A, Salié, H, Athanassopoulos, D, Braun, LM, Javorniczky, RN, Ho, JNHG, Kierdorf, K, Marks, R, Wäsch, R, Simonetta, F, Andrieux, G, Pfeifer, D, Monaco, G, Capitini, C, Fry, TJ, Blank, T, Blazar, BR, Wagner, E, Theobald, M, Sommer, C, Stelljes, M, Reicherts, C, Jeibmann, A, Schittenhelm, J, Monoranu, JM, Rosenwald, A, Kortüm, M, Rasche, L, Einsele, H, Philipp, T, Meyer, PT, Brumberg, J, Völkl, S, Mackensen, A, Coras, R, von Bergwelt-Baildon, M, Albert, NL, Bartos, LM, Brendel, M, Holzgreve, A, Boerries, M, Mackall, CL, Duyster, J, Henneke, P, Priller, J, Köhler, N, Strübing, F, Bengsch, B, Ruella, M, Subklewe, M, von Baumgarten, L, Gill, S, Prinz, M*, & Zeiser, R* Targeting TGF-β-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity-syndrome (ICANS). Nat Cancer, in press (2024).

Categorised in:

This post was written by redakteur