Publications

Boneva SK, Wolf J, Rosmus DD, Schlecht A, Prinz G, Laich Y, Boeck M, Zhang P, Hilgendorf I, Stahl A, Reinhard T, Bainbridge J, Schlunck G, Agostini H, Wieghofer P and Lange CAK: Transcriptional Profiling Uncovers Human Hyalocytes as a Unique Innate Immune Cell Population. Front Immunol, doi.org/10.3389/fimmu.2020.567274 (2020).

Böttcher C*, Fernández-Zapata C*, Snijders GJL, Schlickeiser S, Sneeboer MAM, Kunkel D, De Witte LD*, Priller J*: Single-cell mass cytometry of microglia in major depressive disorder reveals a non-inflammatory phenotype with increased homeostatic marker expression. Transl Psychiatry 10(1), 310; doi: 10.1038/s41398-020-00992-2 (2020).  *equal contribution

Bassett DS, Cullen KE, Eickhoff SB, Farah MJ, Goda Y, Haggard P, Hu H, Hurd YL, Josselyn SA, Khakh BS, Knoblich JA, Poirazi P, Poldrack RA, Prinz M, Roelfsema PR, Spires-Jones TL, Sur M, Ueda HR: Reflections on the past two decades of neuroscience. Nat Rev Neuroci 21(10), 524-534 (2020).

Böttcher C*, van der Poel M*, Fernández-Zapata C*, Schlickeiser S, Leman JKH, Hsiao CC, Mizee MR, Adelia, Vincenten MCJ, Kunkel D, Huitinga I*, Hamann J*, Priller J*: Single-cell mass cytometry reveals complex myeloid cell composition in active lesions of progressive multiple sclerosis. Acta Neuropathol Commun 8, 136; doi: 10.1186/s40478-020-01010-8 (2020). *equal contribution

Ormel PR, Böttcher C, Gigase FAJ, Missall RD, van Zuiden W, Fernández Zapata MC, Ilhan D, de Goeij M, Udine E, Sommer IEC, Priller J, Raj T, Kahn RS, Hol EM, de Witte LD: A characterization of the molecular phenotype and inflammatory response of schizophrenia patient-derived microglia.like cells. Brain Behav Immun. S0889-1591(19)31489-8; doi: 10.1016/j.bbi.2020.08.012 (2020).

Huang Y, Zhang Q, Lubas M, Yuan Y, Yalcin F, Efe IE, Xia P, Motta E, Buonfiglioli A, Lehnardt S, Dzaye O, Flueh C, Synowitz M, Hu F, Kettenmann H: Synergistic Toll-like receptor 3/9 signaling affects properties and impairs glioma-promoting activity of microglia. J Neurosci 40(33):6428-6443 (2020).

Mezö C, Dokalis N, Mossad O, Staszewski O, Neuber J, Yilmaz B, Schnepf D, Gomez de Agüero M, Ganal-Vonarbung SC, Macpherson AJ, Meyer-Luehmann M, Staeheli P, Blank T, Prinz M, Erny D: Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimers’s disease. Acta Neuropathologia Communications 8, 119 (2020).

Masuda T, Amann L, Sankowski R, Staszewski O, Lenz M, d´Errico P, Snaidero N, Jordão MJC, Böttcher C, Kierdorf K, Jung S, Priller J, Misgeld T, Vlachos A, Meyer Luehmann M, Knobeloch KP and Prinz M: Novel Hexb-based tools for studying microglia in the CNS. Nature Immunology 21, 802–815 (2020).

Baasch S, Ruzsics Z and Henneke P: Cytomegaloviruses and Macrophages—Friends and Foes From Early on? Front Immunol 11 (793), doi: 10.3389/fimmu.2020.00793 (2020).

Drost N, Houtman J, Cseresnyés Z, Niesner R, Rinnenthal JL, Miller KR, Prokop S and Heppner FL: The Amyloid-beta rich CNS environment alters myeloid cell functionality independent of their origin. Sci Rep 10: 7152, doi: 10.1038/s41598-020-63989-3 (2020).

Schlecht A, Boneva S, Gruber M, Zhang P, Horres R, Bucher F, Auw-Haedrich C, Hansen L, Stahl A, Hilgendorf I, Agostini H, Wieghofer P, Schlunck G, Wolf J, Lange CAK: Transcriptomic Characterization of Human Choroidal Neovascular Membranes Identifies Calprotectin as a Novel Biomarker for Patients With Age-Related Macular Degeneration. Am J Pathol S0002-9440(20)30201-7, doi: 10.1016/j.ajpath.2020.04.004 (2020).

Amann L, Prinz M: The origin, fate and function of macrophages in the peripheral nervous system – an update. In Immunol  32(11), 709-717 (2020).

Ydens E, Amann L, Asselbergh B, Scott CL, Martens L, Sichien D, Mossad O, Blank T, De Prijck D, Low D, Masuda T, Saeys Y, Timmerman V, Stumm R, Ginhoux F, Prinz M, Janssens S and Guilliams M: Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury. Nature Neuroscience 23, 676–689 (2020).

Dembny P, Newman AG, Singh M, Hinz M, Szczepek M, Krüger C, Adalbert R, Dzaye O,Trimbuch T, Wallach T, Kleinau G, Derkow K, Richard BC, Schipke C, Scheidereit C, Stachelscheid H, Golenbock D, Peters O, Coleman M, Heppner FL, Scheerer P, Tarabykin V, Ruprecht K, Izsvák Z, Mayer J, and Lehnardt S: Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors. JCI Insight 5(7): e131093, doi: 10.1172/jci.insight.131093 (2020).

Hamarsheh S, Osswald L, Saller BS, Unger S, De Feo D, Vinnakota JM, Konantz M, Uhl FM, Becker H, Lübbert M, Shoumariyeh K, Schürch C, Andrieux G, Venhoff N, Schmitt-Graeff A, Duquesne S, Pfeifer D, Cooper MA, Lengerke C, Boerries M, Duyster J, Niemeyer CM, Erlacher M, Blazar BR, Becher B, Groß O, Brummer T and Zeiser R: Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation. Nature Communications 11, 1659 (2020).